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Acid Reflux and Heartburn Natural Remedies - Part 2
If you have acid reflux or heartburn, using natural remedies to rebalance your stomach is what nature intended. Listed are four natural remedies that you can use to rebalance the acid in your stomach.
Cinnamon
Cinnamon has many medicinal...
Alternatiave Medicine - The Healthy Choice
Alternative and Conventional Medicines are the two main systems
of healing in use today and the utmost caution should be taken
to choose wisely.
Being healthy is of crucial importance in the life of everyone.
I do not believe that there is...
Should You Douche?
The only thing a woman can say for certain about her vagina is that it is drenched in mystery. And with this mystery comes a bounty of myths. One myth marring the woman’s body is the concept that her vagina is a filthy pit. Frequent marketing of...
Skin Health Secrets: How to apply skin care products
It is pretty well known that different people get different
results with the same skin care products. This can be caused by
variations in body chemistry, but more often than not it's
because everyone applies skin care products differently.
...
Some Simple Advices About Diet To Reduce Rheumatism
Inflammation is a major component in most Rheumatic pain conditions or rheumatic diseases, therefore it is adviceable to eat a good amount of food that reduces inflammation and reduce the consumption of food that contains inflammatory agents....
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Spironolactone in the treatment of acne
In his article on acne published recently in the New England Journal of Medicine James (1) mentions that androgen antagonist spironolacton is often useful in women with hyperandrogenism. However, it would be important to point out, that the effectiveness of this treatment cannot be determined due to the small sample populations involved in the trials, as has been shown in recent metaanalysis. (2) It should be also emphasized that although the long-term use of spironolactone in the treatment of acne in women appears to be safe, its side-effects seem to be high. (3) On the other hand, it is worth mentioning that spironolactone in addition to its antiandrogenic effects might also have antiinflammatory potential. (4) This emphasizes the need for further properly designed trials with relevant outcomes to provide robust estimates of the size and mechanism of any treatment effects. Because of its long half-life spironolactone should be given once daily and not in divided doses as recommended by James. This might
increase the compliance which is important in prolonged therapy to achieve maximal benefits. (5)
1. James WD. Clinical practice. Acne. N Engl J Med 2005;352:1463-72.
2. Farquhar C, Lee O, Toomath R, Jepson R. Spironolactone versus placebo or in combination with steroids for hirsutism and/or acne. Cochrane Database Syst Rev 2003;(4):CD000194.
3. Shaw JC, White LE. Long-term safety of spironolactone in acne: results of an 8-year followup study. J Cutan Med Surg 2002;6:541-5.
4. Hansen PR, Rieneck K, Bendtzen K. Spironolactone inhibits production of proinflammatory cytokines by human mononuclear cells. Immunol Lett 2004;91:87-91.
5. McEvoy B, Nydegger R, Williams G. Factors related to patient compliance in the treatment of acne vulgaris. Int J Dermatol 2003;42:274-80.
About the author:
Dr. Michal R. Pijak is a consultant in rheumatology, allergy and clinical immunology at the University Hospital in Bratislava, Slovakia.
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