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5 Tips To Cure Your Acne
Reports show that over 90 percent of all adolescents and almost 25 percent of all adults are acne sufferers. And although acne affects about 50 percent of all adult women, acne does affect males and females worldwide, regardless of nationality. ...
Adult Acne Solved!
Acne has always been a dreaded occurrence in our life. Most of us have carried this burden in our teenage years and after almost seven teenage years we think we are finally home free. Then one morning in your twenty sixth, twenty seventh or even...
Detoxification and your skin
Learn to help your body glow from the inside out. Nourish it with foods that are pure and natural. Remove harmful substances from your diet and you will notice a difference in the way you look and feel. What is detoxification? Detoxification is...
The Search for Acne Solutions
Billions of dollars are spent worldwide each year in search of acne solutions. Both consumers and pharmaceutical companies alike are spending the money to find an acne solution that works. Unfortunately, for many, the search is never ending. In most...
Top Tips For Fantastic Skin - Keep Young And Healthy From The Inside Out
When you meet people, what do they see? Your face, your skin, that’s what. Your skin condition can say a lot about your health and your lifestyle. Did you know that your skin is the largest organ of your body? An adult human skin weighs around 5kg...
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Spironolactone in the treatment of acne
In his article on acne published recently in the New England Journal of Medicine James (1) mentions that androgen antagonist spironolacton is often useful in women with hyperandrogenism. However, it would be important to point out, that the effectiveness of this treatment cannot be determined due to the small sample populations involved in the trials, as has been shown in recent metaanalysis. (2) It should be also emphasized that although the long-term use of spironolactone in the treatment of acne in women appears to be safe, its side-effects seem to be high. (3) On the other hand, it is worth mentioning that spironolactone in addition to its antiandrogenic effects might also have antiinflammatory potential. (4) This emphasizes the need for further properly designed trials with relevant outcomes to provide robust estimates of the size and mechanism of any treatment effects. Because of its long half-life spironolactone should be given once daily and not in divided doses as recommended by James. This might
increase the compliance which is important in prolonged therapy to achieve maximal benefits. (5)
1. James WD. Clinical practice. Acne. N Engl J Med 2005;352:1463-72.
2. Farquhar C, Lee O, Toomath R, Jepson R. Spironolactone versus placebo or in combination with steroids for hirsutism and/or acne. Cochrane Database Syst Rev 2003;(4):CD000194.
3. Shaw JC, White LE. Long-term safety of spironolactone in acne: results of an 8-year followup study. J Cutan Med Surg 2002;6:541-5.
4. Hansen PR, Rieneck K, Bendtzen K. Spironolactone inhibits production of proinflammatory cytokines by human mononuclear cells. Immunol Lett 2004;91:87-91.
5. McEvoy B, Nydegger R, Williams G. Factors related to patient compliance in the treatment of acne vulgaris. Int J Dermatol 2003;42:274-80.
About the author:
Dr. Michal R. Pijak is a consultant in rheumatology, allergy and clinical immunology at the University Hospital in Bratislava, Slovakia.
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